Langerin / CD207 (Marker of Langerhans Cells) (LGRN/1821), 1mg/mL

About this product

Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2 -dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG) . BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUM1821-50

Size / count

1x 50 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

C-type lectin domain family 4 member K; CD207; CLEC4K; Langerhans cell specific c type lectin; Langerin

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

CD207

Gene ID

50489

NCBI Gene ID

199731

UniProt

Q9UJ71

Swiss Prot

Q9UJ71

Host

Mouse

Species Reactivity

Human

Reactivity

CD207|Langerin

Immunogen

Recombinant fragment (around aa74-213) of human Langerin protein (exact sequence is proprietary)

Target Antigen

CD207 | Langerin

Clonality

Monoclonal

Clone

LGRN/1821

Type

Primary

Source

Animal

Origin

Animal

Positive Control

HeLa or A549 cells (WB).

Stability

2 years

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

48 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2a, kappa

Species

Mus musculus (mouse)

Classification

PBS, no BSA, no sodium azide (CAS 26628-22-8)

Conjugate

Purified, BSA-free