DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL

Catalog number BNC471869-100

Price for BNC471869-100

Size / count 1x 100 µL

About this product

Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97. 8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94. 4% vs. 94. 7%. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC471869-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Anoctamin 1; Calcium Activated Chloride Channel; Discovered On Gastrointestinal Stromal Tumors Protein 1; TAOS2; ORAOV2; TMEM16A
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TMEM16A
Gene ID: 55107
NCBI Gene ID: 503074
UniProt: Q5XX6
Swiss Prot: Q5XX6
Host: Mouse
Species Reactivity: Human
Reactivity: DOG-1|TMEM16A
Immunogen: Recombinant full-length human DOG-1 protein
Target Antigen: DOG-1 | TMEM16A
Clonality: Recombinant Monoclonal
Clone: RDG1/447
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: Gastrointestinal Stromal Tumor (GIST) or testicular germ cell tumor. Melanocytes in the basal layer of the epidermis and mast cells in the dermis of normal skin.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: ~114 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL?

The catalog number for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL is BNC471869-100.

What sizes are available for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL in stock?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL?

DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL?

The safety data sheet for DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b1061270361e109c04/msds/bnc471869-100.pdf.

What is DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (rDG1/447), CF647 conjugate, 0.1mg/mL used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.