TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL

Catalog number BNUM1921-50

Price for BNUM1921-50

Size / count 1x 50 µL

About this product

Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUM1921-50
Size / count: 1x 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: MSA; TDH2A; Thyroid microsomal antigen; Thyroid peroxidase; Thyroperoxidase; TPO; TPX
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TPO
Gene ID: 7173
NCBI Gene ID: 467554
UniProt: P07202
Swiss Prot: P07202
Host: Mouse
Species Reactivity: Human
Reactivity: TPO
Immunogen: Recombinant fragment of human TPO (around aa 685-804) (Exact sequence is proprietary)
Target Antigen: TPO
Clonality: Monoclonal
Clone: TPO/1921
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: Thyroid Carcinoma
Stability: 2 years
Concentration: 1 mg/mL
Buffer: PBS, no BSA, no azide
Molecular Weight: 100 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse)
Classification: PBS, no BSA, no sodium azide (CAS 26628-22-8)
Conjugate: Purified, BSA-free

Frequently Asked Questions

What is the catalog number for TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL?

The catalog number for TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL is BNUM1921-50.

What sizes are available for TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL?

TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL is available in the following size(s): 1x 50 µL.

Is TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL in stock?

TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL?

TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL is manufactured by Biotium.

What is the estimated delivery time for TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL?

Estimated delivery time for TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL?

The safety data sheet for TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is TPO (Thyroid Peroxidase) (Thyroid Marker) (TPO/1921), 1mg/mL used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.