Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL

Catalog number BNUB1946-500

Price for BNUB1946-500

Size / count 1x 500 µL

About this product

Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUB1946-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ATOD2; Epidermal Filaggrin; Filaggrin; Filaggrin precursor; Fillagrin; FLG; Profilaggrin
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: FLG
Gene ID: 2312
NCBI Gene ID: 654510
UniProt: P20930
Swiss Prot: P20930
Host: Mouse
Species Reactivity: Human
Reactivity: Filaggrin
Immunogen: Recombinant human Filaggrin protein fragment (aa 198-288) (exact sequence is proprietary)
Target Antigen: Filaggrin
Clonality: Recombinant Monoclonal
Clone: RFLG/1561
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: U-251-MG cells. Skin.
Stability: 2 years
Concentration: 0.2 mg/mL
Buffer: PBS, 0.05% BSA, 0.05% azide
Molecular Weight: 26-45 kDa (Processed) ; 350 kDa (Profilaggrin)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Purified, with BSA

Frequently Asked Questions

What is the catalog number for Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL?

The catalog number for Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL is BNUB1946-500.

What sizes are available for Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL?

Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL is available in the following size(s): 1x 500 µL.

Is Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL in stock?

Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL?

Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL is manufactured by Biotium.

What is the estimated delivery time for Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL?

Estimated delivery time for Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL?

The safety data sheet for Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Filaggrin (Keratinocyte Differentiation Marker) (rFLG/1561), 0.2mg/mL used for?

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.