CD40, Mouse (FGK45.5), 0.2mg/mL

About this product

Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4. 5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUB2005-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

B cell surface antigen CD40; CD40 type II isoform; p50; Bp50; CD40L receptor; CDW40; TRAP; IMD3; IGM; Tnfrsf5; HIGM1; GP39; T-BAM

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene ID

21939

UniProt

P27512

Swiss Prot

P27512

Host

Rat

Species Reactivity

Mouse

Reactivity

CD40

Immunogen

Purified recombinant Mouse CD40 fusion protein

Target Antigen

CD40

Clonality

Monoclonal

Clone

FGK45.5

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow, surface (published) |Functional studies (published)

Positive Control

MPBMC's. Spleen, Thymus or Lymph Node.

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

48 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Eur J Immunol (1999) 29: 2835-2841. (functional studies; Flow, surface)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2a, kappa

Species

Rattus norvegicus (laboratory rat), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

Conjugate

Purified, with BSA