CD137, Mouse (LOB12), CF647 conjugate, 0.1mg/mL

About this product

CD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12. 3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivo when administered in combination with immune checkpoint inhibitors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC472012-100

Size / count

1x 100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

4-1BB ligand receptor; 4-1BB; Mouse; homolog; CD137; HLDA VI; induced by lymphocyte activation (ILA) ; Interleukin activated receptor homolog of Mouse Ly63; Ly63; Mouse; Receptor protein 4 1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

Tnfrsf9 (Mouse)

Gene ID

21942

NCBI Gene ID

244187

UniProt

P20334

Swiss Prot

P20334

Host

Rat

Species Reactivity

Mouse

Reactivity

CD137

Immunogen

Murine CD137 human Fc fusion protein

Target Antigen

CD137,

Clonality

Monoclonal

Clone

LOB12

Type

Primary

Source

Animal

Origin

Animal

Applications

Functional studies (published) |ELISA (published)

Positive Control

MPBMC's or Thymus.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

39 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Eur J Immunol (2002) 32: 3617-3627. (functional studies; ELISA)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2a, kappa

Species

Rattus norvegicus (laboratory rat), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF647