P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL

Catalog number BNC682088-500

Price for BNC682088-500

Size / count 1x 500 µL

About this product

The progression of cells through the cell cycle is regulated by a family of proteins designated cyclin-dependent kinases (Cdks) . Sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. Multiple proteins are encoded by the tumor suppressor gene CDKN2A (MTS1/ p16INK4a) via translation of alternate reading frames, resulting in the pro- duction of the p19 ARF protein in mice and the p14 ARF protein in humans. p14 ARF induces an increase in MDM2 and p21 levels and leads to cell cycle arrest in both G1 and G2/M. p14 ARF is negatively regulated by p53 and is known to bind directly to MDM2. CDKN2A also encodes the mitotic protein p16, which binds to and inhibits the Cdk4/cyclin D complex. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC682088-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ARF; CDK4 inhibitor p16 INK4; CDK4I; CDKN2; CDKN2A; Cell cycle negative regulator beta; CMM2; Cyclin dependent kinase 4 inhibitor A; Cyclin dependent kinase inhibitor 2A; INK4; INK4a; Melanoma p16 inhibits CDK4; MLM; MTS 1; MTS1; Multiple tumor suppressor 1; p14; p16; p16 INK4a; p16INK4a; p19; P19ARF; TP16
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: ARF
Gene ID: 1029
NCBI Gene ID: 512599
UniProt: P42771
Swiss Prot: P42771
Host: Mouse
Species Reactivity: Human, Rat
Reactivity: P14ARF
Immunogen: Recombinant full-length human p14 ARF protein
Target Antigen: p14ARF
Clonality: Monoclonal
Clone: 4C6/4
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: MCF7, H1299 and HeLa cells; human prostate carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 14 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2a, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF568

Frequently Asked Questions

What is the catalog number for P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL?

The catalog number for P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL is BNC682088-500.

What sizes are available for P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL?

P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL in stock?

P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL?

P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL?

Estimated delivery time for P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL?

The safety data sheet for P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a3061270361e104f43/msds/bnc682088-500.pdf.

What is P14ARF (4C6/4), CF568 conjugate, 0.1mg/mL used for?

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.