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Product details
Catalog number BNUM2088-50
Price for BNUM2088-50
Size / count 1x 50 µL
The progression of cells through the cell cycle is regulated by a family of proteins designated cyclin-dependent kinases (Cdks) . Sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle. Multiple proteins are encoded by the tumor suppressor gene CDKN2A (MTS1/ p16INK4a) via translation of alternate reading frames, resulting in the pro- duction of the p19 ARF protein in mice and the p14 ARF protein in humans. p14 ARF induces an increase in MDM2 and p21 levels and leads to cell cycle arrest in both G1 and G2/M. p14 ARF is negatively regulated by p53 and is known to bind directly to MDM2. CDKN2A also encodes the mitotic protein p16, which binds to and inhibits the Cdk4/cyclin D complex. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for P14ARF (4C6/4), 1mg/mL is BNUM2088-50.
P14ARF (4C6/4), 1mg/mL is available in the following size(s): 1x 50 µL.
P14ARF (4C6/4), 1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
P14ARF (4C6/4), 1mg/mL is manufactured by Biotium.
Estimated delivery time for P14ARF (4C6/4), 1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for P14ARF (4C6/4), 1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.
The progression of cells through the cell cycle is regulated by a family of proteins designated cyclin-dependent kinases (Cdks) . Sequential activation of individual members of this family and their consequent phosphorylation of critical substrates promotes orderly progression through the cell cycle
Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.
Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.
We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.
