Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL

Catalog number BNC042181-500

Price for BNC042181-500

Size / count 1x 500 µL

About this product

Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Occludin is a tight junction protein that is a key structural component of the blood-brain barrier (BBB) . Degradation of Occludin is frequently seen in ischemic stroke and contributes to BBB disruption. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC042181-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: BLCPMG; Occludin; OCLN; Phosphatase 1 regulatory subunit 115; PTORCH1; Tight junction protein occludin
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: OCLN
Gene ID: 100506658
NCBI Gene ID: 592605
UniProt: Q16625
Swiss Prot: Q16625
Host: Mouse
Species Reactivity: Human
Reactivity: Occludin
Immunogen: Recombinant fragment of human Occludin protein (around aa 282-415) (exact sequence is proprietary)
Target Antigen: Occludin
Clonality: Monoclonal
Clone: OCLN/2181
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified) |WB (verified)
Positive Control: HepG2 cells. Kidney.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 60-82 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL?

The catalog number for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL is BNC042181-500.

What sizes are available for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL?

Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL in stock?

Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL?

Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL?

The safety data sheet for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0298061270361e100a94/msds/bnc042181-500.pdf.

What is Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), CF405S conjugate, 0.1mg/mL used for?

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.