Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL

Catalog number BNUM2181-50

Price for BNUM2181-50

Size / count 1x 50 µL

About this product

Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Occludin is a tight junction protein that is a key structural component of the blood-brain barrier (BBB) . Degradation of Occludin is frequently seen in ischemic stroke and contributes to BBB disruption. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUM2181-50
Size / count: 1x 50 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: BLCPMG; Occludin; OCLN; Phosphatase 1 regulatory subunit 115; PTORCH1; Tight junction protein occludin
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: OCLN
Gene ID: 100506658
NCBI Gene ID: 592605
UniProt: Q16625
Swiss Prot: Q16625
Host: Mouse
Species Reactivity: Human
Reactivity: Occludin
Immunogen: Recombinant fragment of human Occludin protein (around aa 282-415) (exact sequence is proprietary)
Target Antigen: Occludin
Clonality: Monoclonal
Clone: OCLN/2181
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified) |WB (verified)
Positive Control: HepG2 cells. Kidney.
Stability: 2 years
Concentration: 1 mg/mL
Buffer: PBS, no BSA, no azide
Molecular Weight: 60-82 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse)
Classification: PBS, no BSA, no sodium azide (CAS 26628-22-8)
Conjugate: Purified, BSA-free

Frequently Asked Questions

What is the catalog number for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL?

The catalog number for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL is BNUM2181-50.

What sizes are available for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL?

Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL is available in the following size(s): 1x 50 µL.

Is Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL in stock?

Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL?

Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL?

Estimated delivery time for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL?

The safety data sheet for Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0298061270361e100e74/msds/bnum2181-50.pdf.

What is Occludin (Marker of Early Blood Brain Barrier Damage) (OCLN/2181), 1mg/mL used for?

Do you ship this product with dry ice?

Some products, including certain cell lines and biologics, require dry ice for transportation, which carries an additional fee shown clearly in your quotation. Dry ice delivery isn’t always possible to every destination due to transit time or local restrictions, so we check feasibility in advance and you must store the goods at the correct temperature the moment they arrive.

Is this product species cross-reactive?

Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.