Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL

Catalog number BNC942183-500

Price for BNC942183-500

Size / count 1x 500 µL

About this product

Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Up-regulation of epithelial Occludin may play a role in enhancing paracellular permeability and be related to the damage to the tight junction. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC942183-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: BLCPMG; Occludin; OCLN; Phosphatase 1 regulatory subunit 115; PPP1R115; PTORCH1; Tight junction protein occludin
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: OCLN
Gene ID: 100506658
NCBI Gene ID: 592605
UniProt: Q16625
Swiss Prot: Q16625
Host: Mouse
Species Reactivity: Human
Reactivity: Occludin
Immunogen: Recombinant human Occludin fragment around aa 282-415 (Exact sequence is proprietary)
Target Antigen: Occludin
Clonality: Monoclonal
Clone: OCLN/2183
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: HepG2 cells. Kidney.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 60-82 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF594

Frequently Asked Questions

What is the catalog number for Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL?

The catalog number for Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL is BNC942183-500.

What sizes are available for Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL?

Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL in stock?

Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL?

Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL?

Estimated delivery time for Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL?

The safety data sheet for Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Occludin (OCLN) (Tight Junctions Marker) (OCLN/2183), CF594 conjugate, 0.1mg/mL used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.