HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL

Catalog number BNC042187-500

Price for BNC042187-500

Size / count 1x 500 µL

About this product

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4 helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC class II/ dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the sub- sequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (-Microglobulin) . Polymorphisms yield hundreds of HLA-B and -C alleles. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC042187-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DR alpha chain; DRB1; DRB4; HLA class II histocompatibility antigen DR alpha chain; HLA DR1B; HLA DR3B; HLA DRA; HLA-DRA; HLADR4B; HLADRA1; HLADRB; Major histocompatibility complex class II DR alpha; Major histocompatibility complex class II DR beta 1/3/4/5
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: HLA-DR
Gene ID: 3122
NCBI Gene ID: 520048
UniProt: P01903
Swiss Prot: P01903
Host: Mouse
Species Reactivity: Human
Reactivity: HLA-DR
Target Antigen: HLA-DR
Clonality: Monoclonal
Clone: TAL 1B5
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow (verified) |IHC, FFPE (verified) |WB (verified)
Positive Control: Raji, Ramos or Daudi whole cell lysates. Spleen, tonsil or liver tissue lysates. Human melanoma, tonsil or lymph node.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 36 kDa (alpha chain) ; 27 kDa (beta chain) ; 63 kDa (HLA-DR dimer)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL?

The catalog number for HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL is BNC042187-500.

What sizes are available for HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL?

HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL in stock?

HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL?

HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL?

The safety data sheet for HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is HLA-DR (MHC II) (TAL 1B5), CF405S conjugate, 0.1mg/mL used for?

Can this product be used for diagnostic or therapeutic purposes?

No. This product, like all items we supply, is intended for research laboratory use only and must not be used for diagnostics, therapeutics, treatment, or consumption by humans or animals.

What is the shelf life of this product?

Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.

What expression system was used for this recombinant protein?

The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.