HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL

Catalog number BNC472187-100

Price for BNC472187-100

Size / count 1x 100 µL

About this product

Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4 helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC class II/ dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the sub- sequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (-Microglobulin) . Polymorphisms yield hundreds of HLA-B and -C alleles. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC472187-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DR alpha chain; DRB1; DRB4; HLA class II histocompatibility antigen DR alpha chain; HLA DR1B; HLA DR3B; HLA DRA; HLA-DRA; HLADR4B; HLADRA1; HLADRB; Major histocompatibility complex class II DR alpha; Major histocompatibility complex class II DR beta 1/3/4/5
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: HLA-DR
Gene ID: 3122
NCBI Gene ID: 520048
UniProt: P01903
Swiss Prot: P01903
Host: Mouse
Species Reactivity: Human
Reactivity: HLA-DR
Target Antigen: HLA-DR
Clonality: Monoclonal
Clone: TAL 1B5
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow (verified) |IHC, FFPE (verified) |WB (verified)
Positive Control: Raji, Ramos or Daudi whole cell lysates. Spleen, tonsil or liver tissue lysates. Human melanoma, tonsil or lymph node.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 36 kDa (alpha chain) ; 27 kDa (beta chain) ; 63 kDa (HLA-DR dimer)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL?

The catalog number for HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL is BNC472187-100.

What sizes are available for HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL?

HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL in stock?

HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL?

HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL?

The safety data sheet for HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02ac061270361e107fa1/msds/bnc472187-100.pdf.

What is HLA-DR (MHC II) (TAL 1B5), CF647 conjugate, 0.1mg/mL used for?

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.