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Product details
Catalog number BNC942187-100
Price for BNC942187-100
Size / count 1x 100 µL
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4 helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC class II/ dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the sub- sequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (-Microglobulin) . Polymorphisms yield hundreds of HLA-B and -C alleles. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for HLA-DR (MHC II) (TAL 1B5), CF594 conjugate, 0.1mg/mL is BNC942187-100.
HLA-DR (MHC II) (TAL 1B5), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
HLA-DR (MHC II) (TAL 1B5), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
HLA-DR (MHC II) (TAL 1B5), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for HLA-DR (MHC II) (TAL 1B5), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for HLA-DR (MHC II) (TAL 1B5), CF594 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4 helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC class II/ dimers through the a
Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.
Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.
If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.
