Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL

Catalog number BNCB2215-100

Price for BNCB2215-100

Size / count 1x 100 µL

About this product

Recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3, 4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB2215-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: ATN; CMM8; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; Oculocutaneous albinism IA; SHEP3; SK29-AB; Tumor rejection antigen AB; TYR
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: TYR
Gene ID: 7299
NCBI Gene ID: 503555
UniProt: P14679
Swiss Prot: P14679
Host: Mouse
Species Reactivity: Human
Reactivity: Tyrosinase
Immunogen: Recombinant full-length human Tyrosinase protein
Target Antigen: Tyrosinase
Clonality: Recombinant Monoclonal
Clone: ROCA1/812
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: SK-MEL-13, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells. Melanoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 70-80 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL?

The catalog number for Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL is BNCB2215-100.

What sizes are available for Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL?

Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL in stock?

Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL?

Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL?

The safety data sheet for Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Tyrosinase (Melanoma Marker) (rOCA1/812), Biotin conjugate, 0.1mg/mL used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.