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Product details
Catalog number BNC882240-500
Price for BNC882240-500
Size / count 1x 500 µL
Geminin is a nuclear protein that regulates the initiation of DNA replication during the cell cycle. DNA replication requires the coordinated association of Cdc6 and minichromosome maintenance (MCM) proteins with chromatin. Geminin blocks this assembly of the MCM into the prereplication complex and, in turn, prevents replication from occurring. Expression of Geminin fluctuates throughout the cell cycle with Geminin levels lowest at G1. Throughout S, G2 and M phases, Geminin levels are consistently elevated followed by a decrease during mitosis. The initiation of DNA replication is dependent on the degradation of Geminin during mitosis and the absence of Geminin throughout G1 phase. Geminin degradation is mediated by the anaphasepromoting complex (APC), which specifically targets B-type cyclins and other proteins containing a destruction box motif for degradation by ubiquitinmediated proteolysis. While geminin expression is essential in maintaining chromosomal integrity, it is frequently overexpressed in cancers and evidence suggests that it plays a significant role in tumor proliferation and progression. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Geminin / DNA Replication Inhibitor (CPTC-GMMN-1), CF488A conjugate, 0.1mg/mL is BNC882240-500.
Geminin / DNA Replication Inhibitor (CPTC-GMMN-1), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
Geminin / DNA Replication Inhibitor (CPTC-GMMN-1), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Geminin / DNA Replication Inhibitor (CPTC-GMMN-1), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Geminin / DNA Replication Inhibitor (CPTC-GMMN-1), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Geminin / DNA Replication Inhibitor (CPTC-GMMN-1), CF488A conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.
Geminin is a nuclear protein that regulates the initiation of DNA replication during the cell cycle. DNA replication requires the coordinated association of Cdc6 and minichromosome maintenance (MCM) proteins with chromatin. Geminin blocks this assembly of the MCM into the prereplication complex and,
Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.
Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.
Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.
