HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL

Catalog number BNCB2245-500

Price for BNCB2245-500

Size / count 1x 500 µL

About this product

The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes, and the regulation of protein folding. The mitochondrial and cytosolic localization of HSP60, combined with its binding and catalysis of folding of newly synthesized proteins destined for the mitochondrial matrix, classify this protein as a molecular chaperone. An additional role of HSP 60 is to act as a cell surface marker for T cell recognition, as well as being involved in a danger signal cascade immune response. HSP60 has been shown to influence apoptosis in tumor cells, and changes in its expression level may serve as a biomarker, as down-regulated HSP60 expression indicates a poor prognosis as well as a risk of tumor infiltration development, especially with regard to urothelial carcinomas. In ovarian cancer, decreased expression of HSP60 correlates with aggressive tumor types, while overexpression is correlated with a better patient prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB2245-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: 60kDa chaperonin; 60kDa heat shock protein mitochondrial; Chaperonin; 60-KD (CPN60) ; GROEL; HLD4; HSP65; HSPD1; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein; Short heat shock protein 60 Hsp60s1; Spastic paraplegia 13 (SPG13)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: HSPD1
Gene ID: 3329
NCBI Gene ID: 595053
UniProt: P10809
Swiss Prot: P10809
Host: Mouse
Species Reactivity: Human
Reactivity: HSP60
Immunogen: Recombinant full-length human HSPD1 protein
Target Antigen: HSP60
Clonality: Monoclonal
Clone: CPTC-HSPD1-1
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, intracellular (verified) |IF (verified) |IHC, FFPE (verified) |WB (verified)
Positive Control: HEP-2, PC3 or HeLa cells. Breast or Colon Carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 60 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL?

The catalog number for HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL is BNCB2245-500.

What sizes are available for HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL?

HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL in stock?

HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL?

HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL?

The safety data sheet for HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is HSP60 (Heat Shock Protein 60) (Mitochondrial Marker) (CPTC-HSPD1-1), Biotin conjugate, 0.1mg/mL used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.