Product details
Catalog number BNC942247-500
Price for BNC942247-500
Size / count 1x 500 µL
The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP-K) . In humans, NDP kinase A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human C-Myc promotor. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis) (CPTC-NME1-2), CF594 conjugate, 0.1mg/mL is BNC942247-500.
NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis) (CPTC-NME1-2), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis) (CPTC-NME1-2), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis) (CPTC-NME1-2), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis) (CPTC-NME1-2), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for NME1 / nm23-H1 / NDPK-A (Suppressor of Metastasis) (CPTC-NME1-2), CF594 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.
The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells.
Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.
Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.
Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.