8-Oxoguanine DNA Glycosylase (CPTC-OGG1-1), 1mg/mL

About this product

8-Oxoguanine DNA Glycosylase (OGG1), otherwise known as N-Glycosylase/DNA lyase, is the enzyme responsible for the excision of 8-oxoguanine (8-oxoG), a mutagenic base by-product which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversion mutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Defects in OGG1 may be a cause of renal cell carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUM2251-50

Size / count

1x 50 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

8-oxoguanine DNA glycosylase; HMMH; HOGG1; MUTM; OGH1

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

OGG1

Gene ID

4968

NCBI Gene ID

380271

UniProt

O15527

Swiss Prot

O15527

Host

Mouse

Species Reactivity

Human

Reactivity

N-Glycosylase/DNA lyase

Immunogen

Recombinant full-length human OGG1 protein

Target Antigen

N-Glycosylase/DNA lyase

Clonality

Monoclonal

Clone

CPTC-OGG1-1

Type

Primary

Source

Animal

Origin

Animal

Applications

IHC, FFPE (verified)

Positive Control

HeLa or Jurkat cells. Kidney, skin or lymph node.

Stability

2 years

Concentration

1 mg/mL

Buffer

PBS, no BSA, no azide

Molecular Weight

39 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2c, kappa

Species

Mus musculus (mouse)

Classification

PBS, no BSA, no sodium azide (CAS 26628-22-8)

Conjugate

Purified, BSA-free