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Product details
Catalog number BNC472266-100
Price for BNC472266-100
Size / count 1x 100 µL
Calcineurin B homologous protein 2, also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na/H exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Calcineurin B homologous protein 2 / HCC Antigen 520 (CPTC-CHP2-1), CF647 conjugate, 0.1mg/mL is BNC472266-100.
Calcineurin B homologous protein 2 / HCC Antigen 520 (CPTC-CHP2-1), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
Calcineurin B homologous protein 2 / HCC Antigen 520 (CPTC-CHP2-1), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Calcineurin B homologous protein 2 / HCC Antigen 520 (CPTC-CHP2-1), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Calcineurin B homologous protein 2 / HCC Antigen 520 (CPTC-CHP2-1), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Calcineurin B homologous protein 2 / HCC Antigen 520 (CPTC-CHP2-1), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029f061270361e10357f/msds/bnc472266-100.pdf.
Calcineurin B homologous protein 2, also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na/H exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cel
Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.
Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.
If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.
