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Product details
Catalog number BNC402268-500
Price for BNC402268-500
Size / count 1x 500 µL
In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved 'death domain' and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH) . TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions, while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1, for FAS-associated protein factor-1, binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells, FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD, FADD and RIP, FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Fas (TNFRSF6) associated factor 1 (CPTC-FAF1-2), CF640R conjugate, 0.1mg/mL is BNC402268-500.
Fas (TNFRSF6) associated factor 1 (CPTC-FAF1-2), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
Fas (TNFRSF6) associated factor 1 (CPTC-FAF1-2), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Fas (TNFRSF6) associated factor 1 (CPTC-FAF1-2), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Fas (TNFRSF6) associated factor 1 (CPTC-FAF1-2), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Fas (TNFRSF6) associated factor 1 (CPTC-FAF1-2), CF640R conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029a061270361e101a15/msds/bnc402268-500.pdf.
In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved 'death domain' and belonging to the TNF receptor
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