P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL

Catalog number BNCB2275-100

Price for BNCB2275-100

Size / count 1x 100 µL

About this product

This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk's and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma) . Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB2275-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Activating Fragment 1; CAP20; CDK-interacting protein 1; CDKI; CDKN1; CDKN1A; CIP1; Cyclin-dependent kinase inhibitor 1A (p21; Cip1) ; DNA Synthesis Inhibitor; MDA6; Melanoma Differentiation Associated Protein 6; p21Cip1/Waf1; PIC1; SDI1; SLC12A9; Wild type p53 activated fragment 1 (WAF1)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CDKN1A
Gene ID: 1026
NCBI Gene ID: 370771
UniProt: P38936
Swiss Prot: P38936
Host: Rabbit
Species Reactivity: Human
Reactivity: P21WAF1
Immunogen: Recombinant full-length human CDKN1A protein
Target Antigen: p21WAF1
Clonality: Recombinant Monoclonal
Clone: CIP1/2275R
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified) |WB (verified)
Positive Control: HeLa Cells. Skin, colon, or breast carcinoma.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 21 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG
Species: Oryctolagus cuniculus (domestic rabbit), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL?

The catalog number for P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL is BNCB2275-100.

What sizes are available for P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL?

P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL in stock?

P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL?

P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL?

The safety data sheet for P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is P21WAF1 (Tumor Suppressor Protein) (CIP1/2275R), Biotin conjugate, 0.1mg/mL used for?

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Can this product be used for co-immunoprecipitation (Co-IP)?

Suitability for Co-IP depends on the specific antibody and is noted under validated applications on the datasheet. If it isn’t listed, contact our technical support team for guidance based on your target and sample type.