HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL

Catalog number BNC882281-100

Price for BNC882281-100

Size / count 1x 100 µL

About this product

This MAb reacts with a 28 kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC882281-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DRB1; HLA class II histocompatibility antigen; DR-1 beta chain; HLA-DR-beta 1; HLA-DRB1; human leucocyte antigen DRB1; Leucocyte antigen DR beta 1 chain; lymphocyte antigen DRB1; major histocompatibility complex; class II; DR beta 1; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: HLA-DRB1
Gene ID: 3123
NCBI Gene ID: 534322
UniProt: P01911
Swiss Prot: P01911
Host: Mouse
Species Reactivity: Human, Monkey
Reactivity: HLA-DRB
Immunogen: Activated human peripheral blood mononuclear cells
Target Antigen: HLA-DRB
Clonality: Monoclonal
Clone: DA2
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: Ramos, Daudi or HuT78 cells. Tonsil or lymph node
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 28 kDa (beta chain)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF488A

Frequently Asked Questions

What is the catalog number for HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL?

The catalog number for HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL is BNC882281-100.

What sizes are available for HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL?

HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL in stock?

HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL?

HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL?

Estimated delivery time for HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL?

The safety data sheet for HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is HLA-DRB (MHC II) (DA2), CF488A conjugate, 0.1mg/mL used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.