Cdk2 / p34cdc2 Serine-Threonine Kinase (AN4.3), CF647 conjugate, 0.1mg/mL

About this product

In vertebrates, as in yeast, multiple cyclins have been identified, including a total of eight such regulatory proteins in mammals. In contrast to the situation in yeast, the Cdc2 p34 kinase is not the only catalytic subunit identified in vertebrates that can interact with cyclins. While Cdc2 p34 is essential for the G2 to M transition in vertebrate cells, a second Cdc2-related kinase has also been implicated in cell cycle control. This protein, designated cyclindependent kinase 2 (Cdk2), also binds to cyclins and its kinase activity is temporally regulated during the cell cycle. Several additional Cdc2-related cyclin dependent kinases have been identified. These include Cdk3, Cdk4, Cdk5, PCTAIRE-1, PCTAIRE-2, PCTAIRE-3, Cdk6 Cdk7, Cdk8 and KKIALRE. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC472316-100

Size / count

1x 100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Cdc2 related protein kinase; CDC28; CDC2A; CDK1; CDK2; CDKN2; Cell devision kinase 2; Cell division protein kinase 2; cyclin dependent kinase 2 alpha; kinase Cdc2; MPF; p33 protein kinase

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

CDK2

Gene ID

1017

NCBI Gene ID

19192

UniProt

P24941

Swiss Prot

P24941

Host

Mouse

Species Reactivity

Human, Mouse, Xenopus

Reactivity

Cdk2|p34cdc2 Serine-Threonine Kinase

Immunogen

Recombinant full-length human Cdk2 protein

Target Antigen

Cdk2 | p34cdc2 Serine-Threonine Kinase

Clonality

Monoclonal

Clone

AN4.3

Type

Primary

Source

Animal

Origin

Animal

Applications

WB (published)

Positive Control

HeLa cells. HeLa whole cell lysate.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

34 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. Cell Cycle (2016) 15(23):3203-3209. (WB)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG2a, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF647