FAT1 (FAT atypical cadherin 1) (FAT1-3D7/1), 0.2mg/mL

About this product

The FAT proteins are members of the Cadherin superfamily homologous to the Drosophila Fat protein that functions as a positive regulator of planar cell polarity in the Drosophila wing. FAT1 is an unusual cadherin that controls cell growth and planar polarity while acting as a tumor suppressor. FAT1 is a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized at the leading edge of lamellipodia, filopodia and microspike tips where it directly interacts with Ena/VASP proteins to regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, the cytoplasmic domain of FAT1 recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. FAT1 expression in vascular smooth muscle cells (VSMCs) increases significantly after arterial injury or growth factor stimulation, implicating FAT1 in the control of VSMC functions central to vascular remodeling by facilitating migration and limiting proliferation. FAT1 is also involved in psychiatric disorders, and its action may be of pathophysiological importance. This antibody is available purified, with BSA and azide (0.2 mg/mL) or purified, BSA- and azide-free (1 mg/mL) .

Specifications

Catalog number

BNUB2322-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Cadherin family member 7 precursor (CDHF7) ; Cadherin ME5; Cadherin related tumor suppressor homolog precursor (FAT protein homolog) ; FAT tumor suppressor homolog 1; hFat 1; Homolog of Drosophila tumor suppressor FAT precursor; nuclear form; Protein fat homolog; Protocadherin Fat 1

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

FAT1

Gene ID

2195

NCBI Gene ID

481371

UniProt

Q14517

Swiss Prot

Q14517

Host

Mouse

Species Reactivity

Drosophila

Reactivity

FAT1

Immunogen

Cytoplasmic domain of Drosophila Fat protein.

Target Antigen

FAT1

Clonality

Monoclonal

Clone

FAT1-3D7/1

Type

Primary

Source

Animal

Origin

Animal

Positive Control

Wild type imaginal discs from third instar Drosophila larvae.

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

500 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgM, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

Conjugate

Purified, with BSA