GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL

Catalog number BNC042362-500

Price for BNC042362-500

Size / count 1x 500 µL

About this product

This MAb recognizes a protein of 65 kDa, which is identified as glutamic acid decarboxylase 2 (GDA2) . It is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. There are two forms of glutamic acid decarboxylases (GAD's) that are found in the brain: GAD2 (also known as GAD65) and GAD1 (also known as GAD67) . GAD1 and GAD2 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate-limiting step in the production of GABA (-aminobutyric acid) from L-glutamic acid. Although both GAD's are found in the brain, GAD2 localizes to synaptic vesicle membranes in nerve terminals, while GAD1 is distributed throughout the cell. A pathogenic role for GAD2 is identified in the human pancreas since it has been identified as an autoantibody and an auto-reactive T cell target in insulin-dependent diabetes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC042362-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: DCE2; GAD2; Glutamic Acid Decarboxylase 2 (Pancreas) ; Glutamic Acid Decarboxylase 2 (Pancreatic Islets and Brain 65kDa) ; Glutamic Acid Decarboxylase 65 (GAD65)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: GAD2
Gene ID: 2572
NCBI Gene ID: 231829
UniProt: Q05329
Swiss Prot: Q05329
Host: Mouse
Species Reactivity: Human
Reactivity: GAD2|GAD65
Immunogen: Recombinant fragment of human GAD2 (GAD65) protein (around aa 6-99) (exact sequence is proprietary)
Target Antigen: GAD2 | GAD65
Clonality: Monoclonal
Clone: GAD2/2362
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: Pancreas or Brain.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 65 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL?

The catalog number for GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL is BNC042362-500.

What sizes are available for GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL?

GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL in stock?

GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL?

GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL?

The safety data sheet for GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is GAD2 / GAD65 (GABAergic Neuronal Marker) (GAD2/2362), CF405S conjugate, 0.1mg/mL used for?

What is the purity of this recombinant protein?

Purity, typically assessed by SDS-PAGE, is listed on the datasheet under quality control data.

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.