Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL

Catalog number BNC402377-500

Price for BNC402377-500

Size / count 1x 500 µL

About this product

Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC402377-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase; GRIPGHS; Macrophage activation-associated marker protein P71/73; PES-2; PGG/HS; PGHS-2; Prostaglandin endoperoxide synthase 2; Prostaglandin endoperoxide synthase 2 (PTGS2) ; TIS10
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: PTGS2
Gene ID: 5743
NCBI Gene ID: 196384
UniProt: P35354
Swiss Prot: P35354
Host: Mouse
Species Reactivity: Human
Reactivity: Cycloxygenase-2
Immunogen: Recombinant human COX2 protein fragment (around aa 442-572) (exact sequence is proprietary)
Target Antigen: Cycloxygenase-2
Clonality: Monoclonal
Clone: COX2/1941
Type: Primary
Source: Animal
Origin: Animal
Positive Control: Colon or Lung Carcinoma. HepG2 cells.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 70-72 kDa
References & Citations: Wang, D, et al. Oncogene. 2010 Feb 11; 29(6): 781-78
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF640R

Frequently Asked Questions

What is the catalog number for Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL?

The catalog number for Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL is BNC402377-500.

What sizes are available for Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL?

Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL in stock?

Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL?

Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL?

Estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL?

The safety data sheet for Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0295061270361e0ffd29/msds/bnc402377-500.pdf.

What is Cycloxygenase-2 (COX-2) (COX2/1941), CF640R conjugate, 0.1mg/mL used for?

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.