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Product details

Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL

Catalog number BNC942377-100

Price for BNC942377-100

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Size / count 1x 100 µL

About this product

Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number
BNC942377-100
Size / count
1x 100 µL
Dry ice
No
Hazardous
No
Discontinued
No
CAS Number
9007-83-4
Synonyms
Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase; GRIPGHS; Macrophage activation-associated marker protein P71/73; PES-2; PGG/HS; PGHS-2; Prostaglandin endoperoxide synthase 2; Prostaglandin endoperoxide synthase 2 (PTGS2) ; TIS10
UNSPSC
41116161
UNSPSC Description
Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name
PTGS2
Gene ID
5743
NCBI Gene ID
196384
UniProt
P35354
Swiss Prot
P35354
Host
Mouse
Species Reactivity
Human
Reactivity
Cycloxygenase-2
Immunogen
Recombinant human COX2 protein fragment (around aa 442-572) (exact sequence is proprietary)
Target Antigen
Cycloxygenase-2
Clonality
Monoclonal
Clone
COX2/1941
Type
Primary
Source
Animal
Origin
Animal
Positive Control
Colon or Lung Carcinoma. HepG2 cells.
Stability
2 years
Concentration
0.1 mg/mL
Buffer
PBS, 0.1% BSA, 0.05% azide
Molecular Weight
70-72 kDa
References & Citations
Wang, D, et al. Oncogene. 2010 Feb 11; 29(6): 781-78
Shipping Conditions
RT (ND)
Storage Conditions
Stable at room temperature or 37°C (98°F) for 7 days.
Notes
Protect from light
Shelf Life
Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment
IgG2b, kappa
Species
Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification
0.05% sodium azide (CAS 26628-22-8)
Conjugate
CF594

Frequently Asked Questions

What is the catalog number for Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL?

The catalog number for Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL is BNC942377-100.

What sizes are available for Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL?

Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL in stock?

Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL?

Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL?

Estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL?

The safety data sheet for Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is Cycloxygenase-2 (COX-2) (COX2/1941), CF594 conjugate, 0.1mg/mL used for?

Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that

What happens if this product doesn’t perform as expected in my experiment?

Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.

Is this product classed as hazardous or restricted for shipping?

Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.

Can you help me confirm if this product is right for my specific experiment?

Yes, contact us with details of your sample type, species, and intended application, and our specialists will confirm suitability or suggest an alternative from our supplier network if this isn’t the best fit.

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