Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL

Catalog number BNUB2377-100

Price for BNUB2377-100

Size / count 1x 100 µL

About this product

Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUB2377-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase; GRIPGHS; Macrophage activation-associated marker protein P71/73; PES-2; PGG/HS; PGHS-2; Prostaglandin endoperoxide synthase 2; Prostaglandin endoperoxide synthase 2 (PTGS2) ; TIS10
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: PTGS2
Gene ID: 5743
NCBI Gene ID: 196384
UniProt: P35354
Swiss Prot: P35354
Host: Mouse
Species Reactivity: Human
Reactivity: Cycloxygenase-2
Immunogen: Recombinant human COX2 protein fragment (around aa 442-572) (exact sequence is proprietary)
Target Antigen: Cycloxygenase-2
Clonality: Monoclonal
Clone: COX2/1941
Type: Primary
Source: Animal
Origin: Animal
Positive Control: Colon or Lung Carcinoma. HepG2 cells.
Stability: 2 years
Concentration: 0.2 mg/mL
Buffer: PBS, 0.05% BSA, 0.05% azide
Molecular Weight: 70-72 kDa
References & Citations: Wang, D, et al. Oncogene. 2010 Feb 11; 29(6): 781-78
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Purified, with BSA

Frequently Asked Questions

What is the catalog number for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL?

The catalog number for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is BNUB2377-100.

What sizes are available for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL?

Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is available in the following size(s): 1x 100 µL.

Is Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL in stock?

Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL?

Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL?

Estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL?

The safety data sheet for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0296061270361e100018/msds/bnub2377-100.pdf.

What is Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL used for?

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.