Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL

Catalog number BNUB2377-500

Price for BNUB2377-500

Size / count 1x 500 µL

About this product

Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) . Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS) . Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNUB2377-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Glucocorticoid-regulated inflammatory Prostaglandin G/H synthase; GRIPGHS; Macrophage activation-associated marker protein P71/73; PES-2; PGG/HS; PGHS-2; Prostaglandin endoperoxide synthase 2; Prostaglandin endoperoxide synthase 2 (PTGS2) ; TIS10
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: PTGS2
Gene ID: 5743
NCBI Gene ID: 196384
UniProt: P35354
Swiss Prot: P35354
Host: Mouse
Species Reactivity: Human
Reactivity: Cycloxygenase-2
Immunogen: Recombinant human COX2 protein fragment (around aa 442-572) (exact sequence is proprietary)
Target Antigen: Cycloxygenase-2
Clonality: Monoclonal
Clone: COX2/1941
Type: Primary
Source: Animal
Origin: Animal
Positive Control: Colon or Lung Carcinoma. HepG2 cells.
Stability: 2 years
Concentration: 0.2 mg/mL
Buffer: PBS, 0.05% BSA, 0.05% azide
Molecular Weight: 70-72 kDa
References & Citations: Wang, D, et al. Oncogene. 2010 Feb 11; 29(6): 781-78
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Purified, with BSA

Frequently Asked Questions

What is the catalog number for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL?

The catalog number for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is BNUB2377-500.

What sizes are available for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL?

Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is available in the following size(s): 1x 500 µL.

Is Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL in stock?

Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL?

Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is manufactured by Biotium.

What is the estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL?

Estimated delivery time for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL?

The safety data sheet for Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0299061270361e100f8b/msds/bnub2377-500.pdf.

What is Cycloxygenase-2 (COX-2) (COX2/1941), 0.2mg/mL used for?

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.