P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL

Catalog number BNC042378-100

Price for BNC042378-100

Size / count 1x 100 µL

About this product

This MAb recognizes a 21 kDa protein, identified as the p21WAF1 tumor suppressor protein. This MAb is highly specific to p21 and shows no cross-reaction with other closely related mitotic inhibitors. p21WAF1 is a specific inhibitor of cdk's and a tumor suppressor involved in the pathogenesis of a variety of malignancies. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Its expression is induced by the wild type, but not mutant, p53 suppressor protein. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma) . Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC042378-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Activating Fragment 1; CAP20; CDK-interacting protein 1; CDKI; CDKN1; CDKN1A; CIP1; Cyclin-dependent kinase inhibitor 1A (p21; Cip1) ; DNA Synthesis Inhibitor; MDA6; Melanoma Differentiation Associated Protein 6; p21Cip1/Waf1; PIC1; SDI1; SLC12A9; Wild type p53 activated fragment 1 (WAF1)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: CDKN1A
Gene ID: 1026
NCBI Gene ID: 370771
UniProt: P38936
Swiss Prot: P38936
Host: Mouse
Species Reactivity: Human
Reactivity: P21WAF1
Immunogen: Recombinant full-length human CDKN1A protein
Target Antigen: p21WAF1
Clonality: Monoclonal
Clone: AC8
Type: Primary
Source: Animal
Origin: Animal
Positive Control: HeLa or MCF7 cells.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 21 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL?

The catalog number for P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL is BNC042378-100.

What sizes are available for P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL?

P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL in stock?

P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL?

P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL?

The safety data sheet for P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is P21WAF1 (Tumor Suppressor Protein) (AC8), CF405S conjugate, 0.1mg/mL used for?

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.