TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL

Catalog number BNC882399-500

Price for BNC882399-500

Size / count 1x 500 µL

About this product

TIMs are type I transmembrane glycoproteins with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. TIM-3 is expressed on the surface of effector T cells (CD4 Th1 and CD8 Tc1) but not on helper T cells (CD4 Th2 and CD8 Tc2) . In chronic inflammation, autoimmune disorders, and some cancers, TIM-3 is upregulated on several other hematopoietic cell types. The Ig domain of TIM-3 interacts with a ligand on resting but not activated Th1 and Th2 cells. The glycosylated Ig domain of TIM-3 binds cell-associated galectin-9. This induces TIM-3 Tyr phosphorylation and pro-apoptotic signaling. TIM-3 functions as a negative regulator of Th1 cell activity. Its blockade results in increased IFN-gamma production, Th1 cell proliferation and cytotoxicity, regulatory T cell development, and increases in macrophage and neutrophil infiltration into sites of inflammation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC882399-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: CD366; HAVR2; Hepatitis A virus cellular receptor 2 (HAVCR2) ; Kidney injury molecule 3 (KIM3) ; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; TIM3; TIMD3
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: HAVCR2
Gene ID: 84868
NCBI Gene ID: 710500
UniProt: Q8TDQ0
Swiss Prot: Q8TDQ0
Host: Mouse
Species Reactivity: Human
Reactivity: CD366|HAVCR2|TIM3
Immunogen: Recombinant fragment of human TIM3 protein (around aa 22-202) (exact sequence is proprietary)
Target Antigen: CD366 | HAVCR2 | TIM3
Clonality: Monoclonal
Clone: HAVCR2/192
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: PC3, BT474, HepG2, HDLM-2 or Daudi cells. Tonsil, lymph node or spleen.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 60 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2a, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF488A

Frequently Asked Questions

What is the catalog number for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL?

The catalog number for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL is BNC882399-500.

What sizes are available for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL?

TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL in stock?

TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL?

TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL?

Estimated delivery time for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL?

The safety data sheet for TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is TIM3 / HAVCR2 / CD366 (Effector T-Cell Marker) (HAVCR2/192), CF488A conjugate, 0.1mg/mL used for?

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.