STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL

Catalog number BNCB2410-500

Price for BNCB2410-500

Size / count 1x 500 µL

About this product

STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion, formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13, in 55-100% of solitary fibrous tumors, regardless of tumor morphology or anatomical site. By immunohistochemistry, nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges, including meningioma, glioblastoma, gliosarcoma, haemangioblastoma, schwannoma and haemangioma. A recent study by Cheah, et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested, regardless of histology, anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative, demonstrating 100% specificity. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB2410-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: IL4 STAT; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal transducer and activator of transcription 6; STAT interleukin4 induced; STAT6; Transcription factor IL 4 STAT
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: STAT6
Gene ID: 6778
NCBI Gene ID: 524518
UniProt: P42226
Swiss Prot: P42226
Host: Mouse
Species Reactivity: Human
Reactivity: STAT6
Immunogen: Recombinant full-length human STAT6 protein
Target Antigen: STAT6
Clonality: Monoclonal
Clone: STAT6/2410
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: HeLa or HepG2 cells. Kidney
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 119 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL?

The catalog number for STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL is BNCB2410-500.

What sizes are available for STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL?

STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL in stock?

STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL?

STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL?

The safety data sheet for STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is STAT6 (Solitary Fibrous Tumor Marker) (STAT6/2410), Biotin conjugate, 0.1mg/mL used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.