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Product details
Catalog number BNC472470-500
Price for BNC472470-500
Size / count 1x 500 µL
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8 T-cells, natural killer cells and some CD4 T-cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2470), CF647 conjugate, 0.1mg/mL is BNC472470-500.
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2470), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2470), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2470), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2470), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for Perforin-1 (Pore Forming Protein) (Apoptosis Marker) (PRF1/2470), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02af061270361e10914a/msds/bnc472470-500.pdf.
Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9) . Like C9, this protein creates transmembrane tub
Shelf life and expiration dates vary by product and are shown on the product listing and label. Products used beyond their expiration date are not eligible for performance-related returns or refunds, so please check the lot number and expiry before use.
The expression system, such as E. coli, HEK293, or insect cells, is listed on the datasheet under production details, which can affect post-translational modifications relevant to your application.
As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.
