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Product details
Catalog number BNUB2503-100
Price for BNUB2503-100
Size / count 1x 100 µL
CD73 (also designated ecto-5'-nucleotidase, E5NT, NT, NT5, NTE, eN and eNT) is a glycosyl-phosphatidylinositol (GPI) -anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two identical subunits that depends on GPI to link with the external face of the plasma membrane. Similar to other GPI-anchored proteins, CD73 mediates co-stimulatory signals in T cell activation. CD73 has few structural variants, yet elicits diverse biological function through differential regulation in endothelial cells (EC), subpopulations of B and T cells, germinal center follicular dendritic cells and on thymic medullary reticular fibroblasts. For example, IgG mediated neutralization of CD73 interferes with lymphocyte adhesion to EC, and blocks aggregation of germinal center B cells and follicular dendritic cells. Furthermore, IgG-mediated targeting of lymphocyte CD73, but not of endothelial cell CD73, causes shedding of CD73 and tyrosine phosphorylation of proteins. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for CD73 (Immuno-Oncology Target) (NT5E/2503), 0.2mg/mL is BNUB2503-100.
CD73 (Immuno-Oncology Target) (NT5E/2503), 0.2mg/mL is available in the following size(s): 1x 100 µL.
CD73 (Immuno-Oncology Target) (NT5E/2503), 0.2mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
CD73 (Immuno-Oncology Target) (NT5E/2503), 0.2mg/mL is manufactured by Biotium.
Estimated delivery time for CD73 (Immuno-Oncology Target) (NT5E/2503), 0.2mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for CD73 (Immuno-Oncology Target) (NT5E/2503), 0.2mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029d061270361e1028af/msds/bnub2503-100.pdf.
CD73 (also designated ecto-5'-nucleotidase, E5NT, NT, NT5, NTE, eN and eNT) is a glycosyl-phosphatidylinositol (GPI) -anchored adhesion protein that catalyzes the dephosphorylation of extracellular purine and pyrimidine nucleotides to their corresponding bioactive nucleosides. CD73 is a dimer of two
Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.
Send us the catalogue number, product name, lot number, and a summary of your results. Our technical support team will investigate and, where needed, involve the manufacturer. This is covered under our guarantee provided the product was used before its expiry date and stored correctly.
Some products are subject to special import/export regulations, dangerous goods handling, or licensing requirements. Where this applies, it’s noted on the product page, and any required extra documents or fees will be confirmed with you before dispatch, never added without your consent.
