NKX2.8 (NKX28/2547), 0.2mg/mL

About this product

The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUB2547-500

Size / count

1x 500 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Homeobox protein NK 2 homolog H; Homeobox protein NK-2 homolog H; Homeobox protein Nkx 2.8; Homeobox protein Nkx-2.8; NK 2 homolog 8; NK 2 homolog H; NK2 homeobox 8; NK2 transcription factor related; locus 8; Nkx2 9; Nkx2-8; NKX2.8; NKX28_HUMAN; NKX2G; NKX2H; OTTHUMP00000027959

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

NKX2-8

Gene ID

26257

NCBI Gene ID

234763

UniProt

O15522

Swiss Prot

O15522

Host

Mouse

Species Reactivity

Human

Reactivity

NKX2.8

Immunogen

Human recombinant NKX2.8 protein fragment (around aa 10-123) (exact sequence is proprietary)

Target Antigen

NKX2.8

Clonality

Monoclonal

Clone

NKX28/2547

Type

Primary

Source

Animal

Origin

Animal

Applications

WB (verified)

Positive Control

Human Liver, Kidney or Thyroid tissue (IHC).

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

26 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

Conjugate

Purified, with BSA