HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL

Catalog number BNCB2581-100

Price for BNCB2581-100

Size / count 1x 100 µL

About this product

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full-length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum. Its expression in breast cancer, pediatric brain cancer and other types of carcinomas has been reported in studies which suggest ErbB4 expression is involved in both normal tissue development and carcinogenesis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNCB2581-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Avian erythroblastic leukemia viral oncogene homolog 4; HER4; human epidermal growth factor receptor 4; p180erbB4; Proto-oncogene-like protein c-ErbB-4
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: ERBB4
Gene ID: 2066
NCBI Gene ID: 390729
UniProt: Q15303
Swiss Prot: Q15303
Host: Mouse
Species Reactivity: Human
Reactivity: ERBB4|HER-4
Immunogen: Recombinant fragment (around aa 1116-1269) of human ERBB4 (HER4) protein (exact sequence is proprietary)
Target Antigen: ERBB4 | HER-4
Clonality: Monoclonal
Clone: ERBB4/2581
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: Human breast, brain or kidney tissues (IHC).
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 180 kDa (precursor) ; 80/120 kDa (cleaved)
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: Biotin

Frequently Asked Questions

What is the catalog number for HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL?

The catalog number for HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL is BNCB2581-100.

What sizes are available for HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL?

HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL in stock?

HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL?

HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL?

Estimated delivery time for HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL?

The safety data sheet for HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL is available here: https://biotium.com/wp-content/uploads/2018/06/SDS-primary-antibodies.pdf.

What is HER-4 / ERBB4 (ERBB4/2581), Biotin conjugate, 0.1mg/mL used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.