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Product details
Catalog number BNC402608-100
Price for BNC402608-100
Size / count 1x 100 µL
The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs) . A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC) family and include Nrf1 (also designated TCF11), Nrf2 and Nrf3, are bZIP transcription factors that heterodimerize with Maf proteins to bind MARE sequences. The Nrf proteins also bind the antioxidant response element (ARE) and are implicated in the regulation of detoxification enzymes and the oxidative stress response. They do so by heterodimerizing with Jun family members (c-Jun, JunB and JunD) to activate gene expression, specifically the detoxifying enzyme, NQO1. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1. Nrf3 is highly expressed in placenta, B cells and monocytes. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for NRF1 (NRF1/2608), CF640R conjugate, 0.1mg/mL is BNC402608-100.
NRF1 (NRF1/2608), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
NRF1 (NRF1/2608), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
NRF1 (NRF1/2608), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for NRF1 (NRF1/2608), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for NRF1 (NRF1/2608), CF640R conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0297061270361e100960/msds/bnc402608-100.pdf.
The NF-E2 DNA binding protein is composed of two subunits, p45 and MafK, and it regulates expression of globin genes in developing erythroid cells through interaction with Maf recognition elements (MAREs) . A family of NF-E2 related proteins, which are collectively known as the Cap 'n' collar (CNC)
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