MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL

Catalog number BNC472622-100

Price for BNC472622-100

Size / count 1x 100 µL

About this product

Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) . Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC472622-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: BAT26; COCA1; DNA mismatch repair protein Msh2; FCC1; hMSH2; HNPCC1; LCFS2; MSH2; MutS homolog 2; MutS homolog 2 colon cancer nonpolyposis type 1; MutS protein homolog 2
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: MSH2
Gene ID: 4436
NCBI Gene ID: 597656
UniProt: IDP43246
Swiss Prot: IDP43246
Host: Mouse
Species Reactivity: Human
Reactivity: MSH2
Immunogen: Recombinant fragment (around aa 327-427) of human MSH2 protein (exact sequence is proprietary)
Target Antigen: MSH2
Clonality: Monoclonal
Clone: MSH2/2622
Type: Primary
Source: Animal
Origin: Animal
Applications: Flow, intracellular (verified) |IF (verified) |IHC, FFPE (verified) |WB (verified)
Positive Control: A549 or HepG2 cells. Colon, Thyroid, Testis or Lymph Node.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 100 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL?

The catalog number for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL is BNC472622-100.

What sizes are available for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL?

MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL in stock?

MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL?

MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL?

The safety data sheet for MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a3061270361e104e38/msds/bnc472622-100.pdf.

What is MSH2 (DNA Mismatch Repair Marker) (MSH2/2622), CF647 conjugate, 0.1mg/mL used for?

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.