Laminin Receptor / RPSA (Marker of Metastatic Potential) (RPSA/2699), CF405S conjugate, 0.1mg/mL

About this product

Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNC042699-100

Size / count

1x 100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

34/67kDa Laminin Receptor; 37kDa Laminin Receptor precursor; 37/67kDa Laminin Receptor; 37LRP; 40S Ribosomal Protein SA; 67kDa Laminin Receptor; 67LR; Colon Carcinoma Laminin-binding Protein; LAMBR; Laminin receptor 1; Laminin-binding Protein precursor p40; LAMR1; LBP/p40; LRP/LR; Multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; Ribosomal Protein SA (RPSA)

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

RPSA

Gene ID

3921

NCBI Gene ID

449909

UniProt

P08865

Swiss Prot

P08865

Host

Mouse

Species Reactivity

Human

Reactivity

Laminin Receptor|RPSA

Immunogen

Recombinant full-length human RPSA protein

Target Antigen

Laminin Receptor | RPSA

Clonality

Monoclonal

Clone

RPSA/2699

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow (verified) |IF (verified)

Positive Control

MCF-7, MDA-MB-453, SK-BR3, THP1, HL60, HeLa or HEK293 cells. Breast, Colon or Ovarian Carcinoma, Tonsil.

Stability

2 years

Concentration

0.1 mg/mL

Buffer

PBS, 0.1% BSA, 0.05% azide

Molecular Weight

37-67 kDa

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Notes

Protect from light

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgG1, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

0.05% sodium azide (CAS 26628-22-8)

Conjugate

CF405S