Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL

Catalog number BNC402837-500

Price for BNC402837-500

Size / count 1x 500 µL

About this product

Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3) . This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC) . Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC402837-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: 130kDa pemphigus vulgaris antigen (PVA) ; Balding (Bal) ; Cadherin family member 6 (CDHF6) ; Desmoglein-3 (DSG3)
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: DSG3
Gene ID: 1830
NCBI Gene ID: 1925
UniProt: P32926
Swiss Prot: P32926
Host: Mouse
Species Reactivity: Human
Reactivity: Desmoglein-3
Immunogen: Recombinant fragment (around aa 379-491) human DSG3 protein (exact sequence is proprietary)
Target Antigen: Desmoglein-3
Clonality: Monoclonal
Clone: DSG3/2837
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: A431 cells. Skin or Lung Squamous Cell Carcinoma (SCC).
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 130 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG1, kappa
Species: Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF640R

Frequently Asked Questions

What is the catalog number for Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL?

The catalog number for Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL is BNC402837-500.

What sizes are available for Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL?

Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL in stock?

Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL?

Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL?

Estimated delivery time for Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL?

The safety data sheet for Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029e061270361e102f9d/msds/bnc402837-500.pdf.

What is Desmoglein-3 (Squamous Cell Marker) (DSG3/2837), CF640R conjugate, 0.1mg/mL used for?

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

How long will it take to receive this product if it’s custom made?

Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.