Fibrinogen Alpha Chain (UC45), 0.2mg/mL

About this product

The plasma glycoprotein fibrinogen is synthesized in the liver and comprises three structurally different subunits: . Fibrinogen is important in platelet aggregation, the final step of the coagulation cascade (i. e. the formation of fibrin) and determination of plasma viscosity and erythrocyte aggregation. It is both constitutively expressed and inducible during an acute phase reaction. Hemostasis following tissue injury deploys essential plasma procoagulants (prothrombin and factors X, IX, V and VIII), which are involved in a blood coagulation cascade leading to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood clots. The cleavage products of fibrinogen regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number

BNUB2849-100

Size / count

1x 100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9007-83-4

Synonyms

Ac1873; Fba5e; FGA; Fib; Fib2; Fibrinogen alpha chain; Fibrinogen; A alpha polypeptide; Fibrinogen--alpha polypeptide chain; Fibrinopeptide A

UNSPSC

41116161

UNSPSC Description

Primary and secondary antibodies for multiple methodology immunostaining detection application

Gene Name

FGA

Gene ID

2243

NCBI Gene ID

351593

UniProt

P02671

Swiss Prot

P02671

Host

Mouse

Species Reactivity

Human

Reactivity

Fibrinogen Alpha Chain

Immunogen

Human acute monoblastic leukemia cells.

Target Antigen

Fibrinogen Alpha Chain

Clonality

Monoclonal

Clone

UC45

Type

Primary

Source

Animal

Origin

Animal

Applications

Flow (published) |IF (published) |IHC, FFPE (published) |WB (published)

Positive Control

Plasma.

Stability

2 years

Concentration

0.2 mg/mL

Buffer

PBS, 0.05% BSA, 0.05% azide

Molecular Weight

~30 kDa

References & Citations

Note: References for this clone sold by other suppliers may be listed for expected applications. J Exp Med (1983) 157: 473-485. (WB; IF) Cancer Sci (2019) 110(8): 2658-2666. (IHC, FFPE) Neurosci Lett (2015) 602:126-132. (IF; WB) Artificial Cells, Nanomedicine, Biotechnology (2020) 48(1): 28-36. (Flow)

Shipping Conditions

RT (ND)

Storage Conditions

Stable at room temperature or 37°C (98°F) for 7 days.

Shelf Life

Guaranteed for at least 24 months from date of receipt when stored as recommended

Fragment

IgM, kappa

Species

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

Classification

PBS, 0.05% BSA, 0.05% sodium azide (CAS 26628-22-8)

Conjugate

Purified, with BSA