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Product details
Catalog number BNC402864-100
Price for BNC402864-100
Size / count 1x 100 µL
VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells, T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment) . It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2864), CF640R conjugate, 0.1mg/mL is BNC402864-100.
VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2864), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2864), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2864), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2864), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2864), CF640R conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029c061270361e1021ce/msds/bnc402864-100.pdf.
VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both
A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.
Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.
Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.
