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Product details
Catalog number BNC942865-100
Price for BNC942865-100
Size / count 1x 100 µL
VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells, T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment) . It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2865), CF594 conjugate, 0.1mg/mL is BNC942865-100.
VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2865), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2865), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2865), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2865), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for VISTA / GI24 (Negative Regulator of Immune Response) (VISTA/2865), CF594 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a3061270361e104aa6/msds/bnc942865-100.pdf.
VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both
Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.
Lead times depend on the product type: custom polyclonal antibodies typically take 12-14 weeks, monoclonal antibodies 15-17 weeks, made-to-order recombinant proteins 4-8 weeks, and made-to-order recombinant antibodies 6-8 weeks. These are estimates and may shift due to production delays.
A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.
