- Home
- Shop
- New Categories
- New Blog
- Contact Us
- Cart
- Login
- Register
Select the image to view it full size.
Product details
Catalog number BNC942971-500
Price for BNC942971-500
Size / count 1x 500 µL
The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps exp- ressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also medi- ates the transport of the organic anion S- (2, 4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for MRP3 (Multidrug Resistance-Associated Protein 3) (ABCC3/2971), CF594 conjugate, 0.1mg/mL is BNC942971-500.
MRP3 (Multidrug Resistance-Associated Protein 3) (ABCC3/2971), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.
MRP3 (Multidrug Resistance-Associated Protein 3) (ABCC3/2971), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
MRP3 (Multidrug Resistance-Associated Protein 3) (ABCC3/2971), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for MRP3 (Multidrug Resistance-Associated Protein 3) (ABCC3/2971), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for MRP3 (Multidrug Resistance-Associated Protein 3) (ABCC3/2971), CF594 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd0298061270361e100c8e/msds/bnc942971-500.pdf.
The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cyt
Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.
Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.
We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.
