- Home
- Shop
- New Categories
- New Blog
- Contact Us
- Cart
- Login
- Register
Select the image to view it full size.
Product details
Catalog number BNC043007-100
Price for BNC043007-100
Size / count 1x 100 µL
VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells, T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment) . It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF405S conjugate, 0.1mg/mL is BNC043007-100.
VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF405S conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b8061270361e10bf24/msds/bnc043007-100.pdf.
VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both
As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.
Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.
Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.
