VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL

Catalog number BNC943007-100

Price for BNC943007-100

Size / count 1x 100 µL

About this product

VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells, T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment) . It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC943007-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: B7H5; DD1alpha; GI24; PD-1H; PDCD1 homolog; Platelet receptor Gi24; PP2135; Stress-induced secreted protein 1 (SISP1) ; V domain Ig suppressor of T cell activation (VISTA) ; V Set Immuno-Regulatory Receptor
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: VSIR
Gene ID: 64115
NCBI Gene ID: 47382
UniProt: Q9H7M9
Swiss Prot: Q9H7M9
Host: Mouse
Species Reactivity: Human
Reactivity: B7-H5|VISTA|VSIR
Immunogen: Recombinant full-length human VISTA protein
Target Antigen: B7-H5 | VISTA | VSIR
Clonality: Monoclonal
Clone: VISTA/3007
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: Spleen or Placenta.
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 34 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF594

Frequently Asked Questions

What is the catalog number for VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL?

The catalog number for VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL is BNC943007-100.

What sizes are available for VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL?

VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL in stock?

VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL?

VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL?

Estimated delivery time for VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL?

The safety data sheet for VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02a0061270361e103903/msds/bnc943007-100.pdf.

What is VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response) (VISTA/3007), CF594 conjugate, 0.1mg/mL used for?

Is this product tested for endotoxin levels?

Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.

Can I request additional validation data, such as western blot images, for this product?

Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.

What documentation should I request if this product is used for a regulated or intellectual-property-sensitive application?

If the product is subject to intellectual property protections, we’ll advise on any MTA or usage restrictions before shipping. Let us know your intended end use so we can confirm what’s required upfront.