Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL

Catalog number BNC043014-100

Price for BNC043014-100

Size / count 1x 100 µL

About this product

Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC043014-100
Size / count: 1x 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: Cathepsin G-like 1; CCPI; CGL1; CSPB; CTLA-1; CTSGL1; Cytotoxic serine protease B; Cytotoxic T lymphocyte associated serine esterase 1; Cytotoxic T-lymphocyte proteinase 2; Fragmentin-2; GRB; Human lymphocyte protein (Hlp) ; Lymphocyte protease; SECT; T-cell serine protease 1-3E
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: GZMB
Gene ID: 3002
NCBI Gene ID: 1051
UniProt: P10144
Swiss Prot: P10144
Host: Mouse
Species Reactivity: Human
Reactivity: Granzyme B
Immunogen: Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary)
Target Antigen: Granzyme B
Clonality: Monoclonal
Clone: GZMB/3014
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified) |WB (verified)
Positive Control: A431 cells. Human tonsil, spleen or Hodgkin's Lymphoma tissue (IHC).
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: 29-32 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG2b, kappa
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF405S

Frequently Asked Questions

What is the catalog number for Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL?

The catalog number for Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL is BNC043014-100.

What sizes are available for Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL?

Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.

Is Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL in stock?

Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL?

Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL?

Estimated delivery time for Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL?

The safety data sheet for Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b4061270361e10a9e6/msds/bnc043014-100.pdf.

What is Granzyme B (NK/T-Cell Lymphoma Marker) (GZMB/3014), CF405S conjugate, 0.1mg/mL used for?

Does this cell line or biologic require a Material Transfer Agreement (MTA)?

Some products, including certain cell lines, plasmids, and tissue cultures, are subject to intellectual property terms and may require an MTA before we can ship. We’ll inform you in advance if this product requires one, and additional handling fees may apply.

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.