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Product details
Catalog number BNC403022-100
Price for BNC403022-100
Size / count 1x 100 µL
MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2) . When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
The catalog number for MerTK (Innate Immune Checkpoint) (MERTK/3022), CF640R conjugate, 0.1mg/mL is BNC403022-100.
MerTK (Innate Immune Checkpoint) (MERTK/3022), CF640R conjugate, 0.1mg/mL is available in the following size(s): 1x 100 µL.
MerTK (Innate Immune Checkpoint) (MERTK/3022), CF640R conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.
MerTK (Innate Immune Checkpoint) (MERTK/3022), CF640R conjugate, 0.1mg/mL is manufactured by Biotium.
Estimated delivery time for MerTK (Innate Immune Checkpoint) (MERTK/3022), CF640R conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.
The safety data sheet for MerTK (Innate Immune Checkpoint) (MERTK/3022), CF640R conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd02b6061270361e10b9a2/msds/bnc403022-100.pdf.
MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral o
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