MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL

Catalog number BNC473022-500

Price for BNC473022-500

Size / count 1x 500 µL

About this product

MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2) . When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Specifications

Catalog number: BNC473022-500
Size / count: 1x 500 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9007-83-4
Synonyms: CEyk; MER receptor tyrosine kinase; MERK; MERPEN; nmf12; Nyk; Proto-oncogene c-Mer; RP38; STK kinase
UNSPSC: 41116161
UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
Gene Name: MERTK
Gene ID: 10461
NCBI Gene ID: 306178
UniProt: Q12866
Swiss Prot: Q12866
Host: Mouse
Species Reactivity: Human
Reactivity: MerTK
Immunogen: Recombinant human MERTK protein fragment (around aa 55-148) (exact sequence is proprietary)
Target Antigen: MerTK
Clonality: Monoclonal
Clone: MERTK/3022
Type: Primary
Source: Animal
Origin: Animal
Applications: IHC, FFPE (verified)
Positive Control: Human colon tissue (IHC).
Stability: 2 years
Concentration: 0.1 mg/mL
Buffer: PBS, 0.1% BSA, 0.05% azide
Molecular Weight: ~110 kDa
Shipping Conditions: RT (ND)
Storage Conditions: Stable at room temperature or 37°C (98°F) for 7 days.
Notes: Protect from light
Shelf Life: Guaranteed for at least 24 months from date of receipt when stored as recommended
Fragment: IgG
Classification: 0.05% sodium azide (CAS 26628-22-8)
Conjugate: CF647

Frequently Asked Questions

What is the catalog number for MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL?

The catalog number for MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL is BNC473022-500.

What sizes are available for MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL?

MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL is available in the following size(s): 1x 500 µL.

Is MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL in stock?

MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL?

MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL is manufactured by Biotium.

What is the estimated delivery time for MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL?

Estimated delivery time for MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL?

The safety data sheet for MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL is available here: https://cdn.gentaur.com/products/37/68dd029d061270361e1025a1/msds/bnc473022-500.pdf.

What is MerTK (Innate Immune Checkpoint) (MERTK/3022), CF647 conjugate, 0.1mg/mL used for?

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.